Beetroot is naturally high in nitrates and has been shown to boost nitric oxide levels. Two capsules of Prime Flow contain 210mg of beetroot powder.

Watermelon, and specifically watermelon seeds, are naturally high in the amino acid L-Citrulline, a precursor to L-Arginine. Nitric oxide is synthesized from L-arginine by a family of enzymes via the nitric oxide synthase pathway.

Hawthorn contains oligomeric proanthocyanidins that have been shown to have a vasorelaxant effect induced by increased release of nitric oxide through activation of the endothelial nitric oxide synthase (eNOS) pathway.

Each serving of Prime Flow contains more nitrates than one pound of green leafy vegetables. Nitrates are converted to nitrites which are converted to nitric oxide by healthy bacteria in our microbiome, boosting circulating levels of nitric oxide.

The Nobel Prize in Physiology or Medicine was awarded in 1998 to Robert F. Furchgott, Ferid Murad, MD, and Louis J. Ignarro for the discovery of Nitric oxide as a signal molecule. The official press release can be found here: Nobel Prize.